Carcinosarcoma of bladder following long-term cyclophosphamide therapy.

Abstract

Since the advent of long-term cyclophosphamide therapy, an association between this agent and the subsequent development of bladder neoplasms has been documented. Only six sarcomas have been reported, to our knowledge. This report describes the first case in which a leiomyosarcoma and an invasive transitional cell carcinoma (ie, carcinosarcoma) developed in a patient with non-Hodgkin's lymphoma treated with 240 g of cyclophosphamide over a 6.5-year period.

• Authors: S H Sigal, J E Tomaszewski, J J Brooks, A Wein, V A LiVolsi
• Journal: Archives of pathology & laboratory medicine (Arch Pathol Lab Med) Vol. 115 Issue 10 Pg. 1049-51 (Oct 1991) ISSN: 0003-9985 [Print] United States
• PMID: 1898235 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Cyclophosphamide

Topics

• Carcinosarcoma (chemically induced, pathology)
• Cyclophosphamide (adverse effects, therapeutic use)
• Female
• Humans
• Lymphoma, Non-Hodgkin (drug therapy)
• Middle Aged
• Time Factors
• Urinary Bladder Neoplasms (chemically induced, pathology)