Abstract | BACKGROUND: METHODS: One hundred and thirty-five patients with asymptomatic AS were studied. Patients were diagnosed as mild (n = 18, aortic valve area [AVA] > or =1.5 cm(2)), moderate (n = 57, AVA 1.0-1.49 cm(2)), or severe AS (n = 60, AVA <1.0 cm(2)) by Doppler echocardiography. Patients with serial (baseline and at 1 year) echocardiographic examination (n = 47) were grouped as either slow (n = 22, DeltaAVA <-0.15 cm(2)/y) or rapid progression group (n = 25, DeltaAVA > or =-0.15 cm(2)/y). In addition, long-term prognosis was compared between patients with low CRP (n = 68, CRP <0.15 mg/dL) and those with high CRP (n = 67, CRP > or =0.15 mg/dL). RESULTS: Baseline CRP was significantly higher in patients with severe AS than in those with mild or moderate AS (mild AS 0.17 +/- 0.43, moderate AS 0.22 +/- 0.28, severe AS 0.53 +/- 0.66 mg/dL, P = .001). By multivariate logistic regression analysis, CRP was an independent predictor of severe AS (odds ratio 3.51, P = .015). Similarly, CRP was significantly higher in the rapid progression group than in the slow progression group (0.56 +/- 0.76 vs 0.19 +/- 0.25 mg/dL, P = .004). Furthermore, long-term survival was significantly lower in the high CRP group than in the low CRP group (log rank: P < .001). CONCLUSION:
C-Reactive protein predicts severity, progression, and prognosis in patients with asymptomatic AS.
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Authors | Koichiro Imai, Hiroyuki Okura, Teruyoshi Kume, Ryotaro Yamada, Yoshinori Miyamoto, Takahiro Kawamoto, Nozomi Watanabe, Yoji Neishi, Eiji Toyota, Kiyoshi Yoshida |
Journal | American heart journal
(Am Heart J)
Vol. 156
Issue 4
Pg. 713-8
(Oct 2008)
ISSN: 1097-6744 [Electronic] United States |
PMID | 18926152
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Aortic Valve Stenosis
(blood, diagnostic imaging, mortality)
- C-Reactive Protein
(analysis)
- Disease Progression
- Female
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Multivariate Analysis
- Odds Ratio
- Predictive Value of Tests
- Prognosis
- Severity of Illness Index
- Ultrasonography
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