A novel report of cig-FISH and cytogenetics in POEMS syndrome.

Abstract

POEMS syndrome is a plasma cell proliferative disorder whose pathogenesis is poorly understood. We provide the first report of cytoplasmic immunoglobulin/FISH testing (cIg-FISH) in POEMS syndrome using established myeloma markers. We reviewed all 37 POEMS cases seen at our institution in which cIg-FISH testing had been obtained. Monosomy 13 was seen in 14 of the 37 (38%) cIg-FISH samples. One patient had trisomy 3 and 7. Three patients had IgH translocation t(11;14)(q13;q32). No abnormalities were seen at 17p13(p53). The monosomy 13 is in line with other plasma cell disorders while the low prevalence of hyperdiploidy and abnormalities at 14q32 is unique.

• Authors: Alan H Bryce, Rhett P Ketterling, Morie A Gertz, Martha Lacy, Ryan A Knudson, Shaji Kumar, Robert A Kyle, Rafael Fonseca, Phillip R Greipp, John A Lust, Vincent S Rajkumar, Suzanne R Hayman, Francis Buadi, Stephen J Russell, Stephen R Zeldenrust, Angela Dispenzieri
• Journal: American journal of hematology (Am J Hematol) Vol. 83 Issue 11 Pg. 840-1 (Nov 2008) ISSN: 1096-8652 [Electronic] United States
• PMID: 18839437 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2008 Wiley-Liss, Inc.

Topics

• Adult
• Aged
• Chromosome Aberrations
• Chromosomes, Human, Pair 11 (genetics)
• Chromosomes, Human, Pair 13 (genetics)
• Cohort Studies
• Female
• Humans
• In Situ Hybridization, Fluorescence
• Male
• Middle Aged
• POEMS Syndrome (genetics)