MASPIN's prognostic role in patients with advanced head and neck carcinoma treated with primary chemotherapy (carboplatin plus vinorelbine) and radiotherapy: preliminary evidence.

Abstract

CONCLUSIONS:

Our very preliminary results support the hypothesis that MASPIN expression in primary head and neck squamous cell carcinoma (HNSCC) may be a valuable parameter for predicting patients' responses to a treatment based on carboplatin plus vinorelbine combined with radiotherapy.

OBJECTIVES:

The roles of induction chemotherapy and combined chemoradiotherapy in the treatment of locally advanced unresectable HNSCCs have evolved rapidly. MASPIN has a unique tumour-suppressing activity. Experimental evidence has shown that MASPIN suppresses tumour growth, angiogenesis, invasion and metastasis. We investigated the potential prognostic roles of MASPIN and p53 in a series of HNSCCs treated with carboplatin plus vinorelbine combined with radiotherapy.

PATIENTS AND METHODS:

Nineteen consecutive stage III or IV HNSCC patients were recruited. The treatment plan consisted of the administration of carboplatin on day 1 and vinorelbine on days 1 and 8. Four weeks later, carboplatin was administered concomitantly with radiation therapy. Expression of MASPIN and p53 was determined immunohistochemically in HNSCC diagnostic biopsies.

RESULTS:

A significant inverse relation was found between MASPIN expression and cN staging (p = 0.003). From a prognostic viewpoint, MASPIN expression was directly correlated with chemoradiotherapy response (p = 0.041). Moreover, the log-rank test showed a significant relationship between higher MASPIN expression and longer disease-free survival (p = 0.03), overall survival (p = 0.006) and disease-specific survival (p = 0.007).

• Authors: Gino Marioni, Haralabos Koussis, Elena Gaio, Luciano Giacomelli, Andy Bertolin, Emiliano D'Alessandro, Annamaria Scola, Giancarlo Ottaviano, Cosimo de Filippis, Antonio Jirillo, Alberto Staffieri, Stella Blandamura
• Journal: Acta oto-laryngologica (Acta Otolaryngol) Vol. 129 Issue 7 Pg. 786-92 (Jul 2009) ISSN: 1651-2251 [Electronic] England
• PMID: 18819022 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• SERPIN-B5
• Serine Proteinase Inhibitors
• Serpins
• Tumor Suppressor Protein p53
• Vinblastine
• Carboplatin
• Vinorelbine

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biomarkers, Tumor (analysis)
• Carboplatin (administration & dosage)
• Carcinoma, Squamous Cell (drug therapy, pathology, radiotherapy)
• Combined Modality Therapy
• Female
• Humans
• Image Processing, Computer-Assisted
• Male
• Middle Aged
• Neoplasm Staging
• Otorhinolaryngologic Neoplasms (drug therapy, pathology, radiotherapy)
• Prognosis
• Serine Proteinase Inhibitors (analysis)
• Serpins (analysis)
• Tumor Suppressor Protein p53 (analysis)
• Vinblastine (administration & dosage, analogs & derivatives)
• Vinorelbine