FDG-PET predicts survival and distant metastasis in oral squamous cell carcinoma.

Abstract

High [(18)F]-2-fluorodeoxyglucose (FDG)-uptake of primary tumor, assessed by pretreatment positron emission tomography (PET), shows poor overall survival of patients after several therapies in various cancers. An association between FDG-uptake and distant metastasis-free survival in oral squamous cell carcinoma (OSCC) has not been assessed so far. An objective of this study is to investigate an association between FDG-uptake and overall survival of OSCC patients, and to ask whether FDG-uptake is related with distant metastasis-free survival in OSCC. Twenty-four patients who underwent both pretreatment FDG-PET and radical surgery without preoperative therapy were enrolled. We used the maximum standardized uptake value (SUVmax) as FDG-uptake. Overall survival, locoregional recurrence-free survival and distant metastasis-free survival were analyzed by Kaplan-Meier method. In univariate survival analysis, patients with SUVmax>or=12 exhibited significance in both shorter 3-year overall survival (p<0.01) and distant metastasis-free survival (p<0.04) than patients with SUVmax<12. Moreover, by Cox proportional hazards model of multivariate analysis, SUVmax>or=12 was found to be independent of clinical T and N categories, and exhibited significance in both shorter 3-year overall survival (p<0.02) and distant metastasis- free survival (p<0.05) than patients with SUVmax<12. These results suggest that pretreatment FDG-PET is able to provide both non-invasive and effective information for identifying a high- or low-risk group of OSCC patients with distant metastasis.

• Authors: Hidenori Suzuki, Yasuhisa Hasegawa, Akihiro Terada, Ikuo Hyodo, Tsutomu Nakashima, Masami Nishio, Tsuneo Tamaki
• Journal: Oral oncology (Oral Oncol) Vol. 45 Issue 7 Pg. 569-73 (Jul 2009) ISSN: 1879-0593 [Electronic] England
• PMID: 18804407 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Radiopharmaceuticals
• Fluorodeoxyglucose F18

Topics

• Aged, 80 and over
• Carcinoma, Squamous Cell (diagnostic imaging, metabolism, mortality, secondary)
• Disease-Free Survival
• Female
• Fluorodeoxyglucose F18 (pharmacokinetics)
• Humans
• Japan
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Mouth Neoplasms (diagnostic imaging, metabolism, mortality)
• Positron-Emission Tomography (methods)
• Prognosis
• Radiopharmaceuticals (pharmacokinetics)