Modification of the side chain of micromolide, an anti-tuberculosis natural product.

Abstract

This paper describes a series of modifications of the side chain of micromolide, an anti-tuberculosis natural product. Most of the synthesized compounds showed significantly decreased activities, which suggests that the long aliphatic side chain of micromolide and its double bond are essential to its activity.

• Authors: Hai Yuan, Rong He, Baojie Wan, Yuehong Wang, Guido F Pauli, Scott G Franzblau, Alan P Kozikowski
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 18 Issue 19 Pg. 5311-5 (Oct 01 2008) ISSN: 1464-3405 [Electronic] England
• PMID: 18774716 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkenes
• Antitubercular Agents
• Biological Products
• Lactones
• micromolide

Topics

• Alkenes (chemical synthesis, chemistry, pharmacology)
• Antitubercular Agents (chemical synthesis, chemistry, pharmacology)
• Biological Products (chemistry)
• Combinatorial Chemistry Techniques
• Lactones (chemical synthesis, chemistry, pharmacology)
• Molecular Structure
• Plants, Medicinal (chemistry)
• Structure-Activity Relationship
• Tuberculosis (drug therapy)