Adjuvant oral clodronate improves the overall survival of primary breast cancer patients with micrometastases to the bone marrow: a long-term follow-up.

Abstract

BACKGROUND:

Adding oral clodronate to postoperative adjuvant breast cancer therapy significantly improves disease-free survival (DFS) and overall survival (OS). Long-term follow-up data from the prospective, randomized, controlled study are reported.

PATIENTS AND METHODS:

Patients with primary breast cancer received clodronate 1600 mg/day for 2 years or no treatment along with standard adjuvant breast cancer treatment.

RESULTS:

Analysis of 290 of 302 patients demonstrated that a significant improvement in OS was maintained in the clodronate group at a median follow-up of 103 +/- 12 months; 20.4% of patients in the clodronate group versus 40.7% of control group patients (P = 0.04) died during the 8.5 years following primary surgical therapy. Significant reductions in the incidence of bony and visceral metastases and improvement in duration of DFS at 36- and 55-month follow-up periods were no longer seen with clodronate.

CONCLUSION:

These long-term survival data extend the survival advantage reported in previous studies with oral clodronate in breast cancer.

• Authors: I J Diel, A Jaschke, E F Solomayer, C Gollan, G Bastert, C Sohn, F Schuetz
• Journal: Annals of oncology : official journal of the European Society for Medical Oncology (Ann Oncol) Vol. 19 Issue 12 Pg. 2007-11 (Dec 2008) ISSN: 1569-8041 [Electronic] England
• PMID: 18664560 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Bone Density Conservation Agents
• Clodronic Acid

Topics

• Administration, Oral
• Adult
• Aged
• Antineoplastic Agents (therapeutic use)
• Bone Density Conservation Agents (administration & dosage)
• Bone Marrow (pathology)
• Bone Neoplasms (epidemiology, prevention & control)
• Breast Neoplasms (mortality, pathology, therapy)
• Chemotherapy, Adjuvant (methods)
• Clodronic Acid (administration & dosage)
• Combined Modality Therapy
• Disease-Free Survival
• Female
• Follow-Up Studies
• Humans
• Incidence
• Kaplan-Meier Estimate
• Mastectomy
• Middle Aged
• Radiotherapy