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Adjuvant oral clodronate improves the overall survival of primary breast cancer patients with micrometastases to the bone marrow: a long-term follow-up.

AbstractBACKGROUND:
Adding oral clodronate to postoperative adjuvant breast cancer therapy significantly improves disease-free survival (DFS) and overall survival (OS). Long-term follow-up data from the prospective, randomized, controlled study are reported.
PATIENTS AND METHODS:
Patients with primary breast cancer received clodronate 1600 mg/day for 2 years or no treatment along with standard adjuvant breast cancer treatment.
RESULTS:
Analysis of 290 of 302 patients demonstrated that a significant improvement in OS was maintained in the clodronate group at a median follow-up of 103 +/- 12 months; 20.4% of patients in the clodronate group versus 40.7% of control group patients (P = 0.04) died during the 8.5 years following primary surgical therapy. Significant reductions in the incidence of bony and visceral metastases and improvement in duration of DFS at 36- and 55-month follow-up periods were no longer seen with clodronate.
CONCLUSION:
These long-term survival data extend the survival advantage reported in previous studies with oral clodronate in breast cancer.
AuthorsI J Diel, A Jaschke, E F Solomayer, C Gollan, G Bastert, C Sohn, F Schuetz
JournalAnnals of oncology : official journal of the European Society for Medical Oncology / ESMO (Ann Oncol) Vol. 19 Issue 12 Pg. 2007-11 (Dec 2008) ISSN: 1569-8041 [Electronic] England
PMID18664560 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Bone Density Conservation Agents
  • Clodronic Acid
Topics
  • Administration, Oral
  • Adult
  • Aged
  • Antineoplastic Agents (therapeutic use)
  • Bone Density Conservation Agents (administration & dosage)
  • Bone Marrow (pathology)
  • Bone Neoplasms (epidemiology, prevention & control)
  • Breast Neoplasms (mortality, pathology, therapy)
  • Chemotherapy, Adjuvant (methods)
  • Clodronic Acid (administration & dosage)
  • Combined Modality Therapy
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Kaplan-Meier Estimate
  • Mastectomy
  • Middle Aged
  • Radiotherapy

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