Wound management with N-carboxybutyl chitosan.

Abstract

In patients undergoing plastic surgery, donor sites were treated with soft pads of freeze-dried N-carboxybutyl chitosan to promote ordered tissue regeneration. Compared to control donor sites, better histoarchitectural order, better vascularization and the absence of inflammatory cells were observed at the dermal level, whilst fewer aspects of proliferation of the malpighian layer were reported at the epidermal level. Accordingly, N-carboxybutyl chitosan leads to formation of regularly organized cutaneous tissue and reduces anomalous healing.

• Authors: G Biagini, A Bertani, R Muzzarelli, A Damadei, G DiBenedetto, A Belligolli, G Riccotti, C Zucchini, C Rizzoli
• Journal: Biomaterials (Biomaterials) Vol. 12 Issue 3 Pg. 281-6 (Apr 1991) ISSN: 0142-9612 [Print] Netherlands
• PMID: 1854896 (Publication Type: Journal Article)

Chemical References

• N-carboxybutyl chitosan
• Chitin
• Collagen
• Chitosan

Topics

• Adult
• Biological Dressings
• Chitin (analogs & derivatives)
• Chitosan
• Collagen (ultrastructure)
• Female
• Fibroblasts (ultrastructure)
• Humans
• Male
• Microscopy, Electron
• Middle Aged
• Skin (ultrastructure)
• Skin Transplantation (methods, physiology)
• Surgery, Plastic (methods)
• Thigh
• Wound Healing (physiology)