Abstract | PURPOSE: To our knowledge, there are no published data pertinent to the use of [( 18F)]fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in patients with natural killer (NK)/ T-cell lymphoma. The purpose of this study was to assess the value of FDG PET/CT in this aggressive type of non-Hodgkin lymphoma. PATIENTS AND METHODS: All patients with NK/ T-cell lymphoma referred for FDG PET/CT at our institution from July 2001 to July 2006 were retrospectively studied. PET/CT examinations were blindly reviewed by 2 experienced readers. The results were compared with the status of the disease, which was determined after evaluation of biopsy, laboratory, clinical and conventional imaging examination, and follow-up results. PET/CT results were thereby classified as true-positive, true-negative, false-positive, or false-negative. The degree of FDG uptake in the positive lesions was semiquantified using maximum standard uptake value (SUV(max)). RESULTS: Twenty-one PET/CT examinations were performed in 10 patients with NK/ T-cell lymphoma. For nasal disease, PET/CT was true-positive in 5 cases, true-negative in 15 cases, and positive but unconfirmed in 1 case. For extranasal disease, PET/CT was true-positive in 3 cases, true-negative in 16 cases, and false-negative in 2 cases. The mean SUV(max) in PET-positive lesions in nasal cavities or paranasal sinuses was 16 gm/mL (range, 5-25 gm/mL; median, 19.3 gm/mL). In extranasal disease, the mean SUV(max) was 10.9 gm/mL (range, 4.6-34.1 gm/mL; median, 5.6 gm/mL). CONCLUSION: Viable NK/ T-cell lymphoma is intensely FDG hypermetabolic. PET/CT appears to be sensitive for the detection of disease in the nasopharynx and, to a lesser extent, in extranasal sites.
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Authors | Dimitrios Karantanis, Rathan M Subramaniam, Patrick J Peller, Val J Lowe, Jolanta M Durski, Douglas A Collins, Evangelos Georgiou, Stephen M Ansell, Gregory A Wiseman |
Journal | Clinical lymphoma & myeloma
(Clin Lymphoma Myeloma)
Vol. 8
Issue 2
Pg. 94-9
(Apr 2008)
ISSN: 1557-9190 [Print] United States |
PMID | 18501102
(Publication Type: Journal Article)
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Chemical References |
- Radioisotopes
- Fluorodeoxyglucose F18
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Topics |
- Adult
- Female
- Fluorodeoxyglucose F18
- Humans
- Killer Cells, Natural
(diagnostic imaging)
- Lymphoma, T-Cell
(diagnostic imaging)
- Male
- Middle Aged
- Positron-Emission Tomography
(methods)
- Radioisotopes
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