Genetic polymorphisms in the CD40 ligand gene and Kawasaki disease.

Abstract

BACKGROUND:

Although some previous studies have reported that genetic and immunological factors play important roles in the pathogenesis of Kawasaki disease (KD), the etiological factors of this enigmatical pediatric disease are still poorly understood.

PURPOSE:

This study aims to investigate whether polymorphisms of the CD40 ligand (CD40L) gene are associated with KD and the development of coronary artery lesions (CAL) in the Taiwanese children.

MATERIALS AND METHODS:

The CD40L -3459 A/G and IVS4+121 A/G single nucleotide polymorphisms (SNPs) were genotyped in 167 children with KD and 1,010 ethnically matched healthy controls by TaqMan assay.

RESULTS:

None of the CD40L polymorphisms was associated with susceptibility or CAL development of KD, and this finding was supported by the haplotype analysis.

CONCLUSION:

In summary, these results provide little support for specific CD40L SNPs in the susceptibility or CAL development of KD in Taiwanese children. However, it will be necessary to validate or replicate this association in other independent large-size ethnic groups.

• Authors: Fu-Yuan Huang, Tzu-Yang Chang, Ming-Ren Chen, Nan-Chang Chiu, Hsin Chi, Hung-Chang Lee, Shuan-Pei Lin, Chih-Kai Chen, Hui-Wen Chan, Wei-Fang Chen, Hsin-Fu Liu, Chen-Chung Chu, Marie Lin, Yann-Jinn Lee
• Journal: Journal of clinical immunology (J Clin Immunol) Vol. 28 Issue 5 Pg. 405-10 (Sep 2008) ISSN: 0271-9142 [Print] Netherlands
• PMID: 18481160 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CD40 Ligand

Topics

• Adult
• Asian People
• CD40 Ligand (genetics, immunology)
• Child
• Child, Preschool
• Coronary Stenosis (genetics, immunology)
• Female
• Genetic Predisposition to Disease
• Humans
• Infant
• Male
• Middle Aged
• Mucocutaneous Lymph Node Syndrome (genetics, immunology, physiopathology)
• Polymorphism, Single Nucleotide
• Taiwan