Long-term survival in patients with locally advanced colon cancer after en bloc pancreaticoduodenectomy and colectomy.

Abstract

PURPOSE:

Surgical indications for colon cancer directly invading the pancreas head are controversial.

METHODS:

Between 1957 and 2007, a total of 12 patients (8 men) underwent pancreaticoduodenectomy combined with right hemicolectomy for colon cancer involving the pancreas head.

RESULTS:

Mean age was 58 (range, 34-77) years. Fistula formation was observed in five patients (41 percent) preoperatively. Tumor involvement was duodenum only (n = 4), duodenum/pancreas (n = 3), stomach/pancreas (n = 1), duodenum/stomach (n = 2), duodenum/liver (n = 1), and pancreas only (n = 1). Only one postoperative death was encountered. Histologic examination showed malignant invasion to the pancreas head in nine cases (75 percent). Overall one-year, three-year and, five-year survival rates after surgery were 75, 66, and 55 percent, respectively. Five patients (41 percent) survived for more than ten 10 years.

CONCLUSIONS:

Pancreaticoduodenectomy for advanced colon cancer invading the pancreas or duodenum provides favorable long-term survival.

• Authors: Akio Saiura, Junji Yamamoto, Masashi Ueno, Rintaro Koga, Makoto Seki, Norihiro Kokudo
• Journal: Diseases of the colon and rectum (Dis Colon Rectum) Vol. 51 Issue 10 Pg. 1548-51 (Oct 2008) ISSN: 1530-0358 [Electronic] United States
• PMID: 18454292 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Colectomy (methods)
• Colonic Neoplasms (mortality, surgery)
• Humans
• Male
• Middle Aged
• Neoplasm Invasiveness
• Pancreatic Neoplasms (mortality, surgery)
• Pancreaticoduodenectomy (methods)
• Retrospective Studies
• Survival Rate
• Treatment Outcome