Toll-like receptors and fungal infections: the role of TLR2, TLR4 and MyD88 in paracoccidioidomycosis.

Abstract

The aim of this minireview is to present a concise view of the most important pattern recognition receptors used by the innate immune system to sense and control pathogen growth into host tissues. A brief review of the role of Toll-like receptors (TLRs) in fungal infections followed by some recent results on the function of TLR4, TLR2 and the MyD88 adaptor molecule in the pathogenesis of paracoccidioidomycosis are presented.

• Authors: Vera L G Calich, Adriana Pina, Maíra Felonato, Simone Bernardino, Tania A Costa, Flávio V Loures
• Journal: FEMS immunology and medical microbiology (FEMS Immunol Med Microbiol) Vol. 53 Issue 1 Pg. 1-7 (Jun 2008) ISSN: 0928-8244 [Print] England
• PMID: 18384366 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Myd88 protein, mouse
• Myeloid Differentiation Factor 88
• Tlr2 protein, mouse
• Tlr4 protein, mouse
• Toll-Like Receptor 2
• Toll-Like Receptor 4

Topics

• Animals
• Humans
• Immunity, Innate
• Myeloid Differentiation Factor 88 (immunology)
• Paracoccidioides (immunology)
• Paracoccidioidomycosis (immunology)
• Toll-Like Receptor 2 (immunology)
• Toll-Like Receptor 4 (immunology)