Eosinophilic pneumonia (EP) associated with rheumatoid arthritis in which drug-induced eosinophilic pneumonia could be ruled out.

Abstract

A 72 year-old man. He was diagnosed with rheumatoid arthritis in 2002. In January 2005 he noted productive cough and fever; he was diagnosed as eosinophilic pneumonia (EP). We discontinued administration of bucillamine and methotrexate and started to treat with oral prednisolone 30 mg daily. To rule out drug-induced EP, prednisolone was tapered by 10 mg per week. Consolidation occurred in the right lower lobe when prednisolone was decreased to 5 mg daily. After increasing the dose of prednisolone to 30 mg daily again, consolidation was promptly resolved. It was considered to be important to rule out drug-induced EP.

• Authors: Yuichi Tambo, Masaki Fujimura, Masahide Yasui, Kazuo Kasahara, Yasuto Nakatsumi, Shinji Nakao
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 47 Issue 6 Pg. 527-31 ( 2008) ISSN: 1349-7235 [Electronic] Japan
• PMID: 18344640 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antirheumatic Agents
• Glucocorticoids
• Prednisolone
• Cysteine
• bucillamine
• Methotrexate

Topics

• Aged
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Antirheumatic Agents (therapeutic use)
• Arthritis, Rheumatoid (complications, drug therapy)
• Cysteine (analogs & derivatives, therapeutic use)
• Diagnosis, Differential
• Glucocorticoids (adverse effects, therapeutic use)
• Humans
• Male
• Methotrexate (therapeutic use)
• Prednisolone (adverse effects, therapeutic use)
• Pulmonary Eosinophilia (chemically induced, diagnosis, etiology)