Superoxidase dismutase (SOD) topical use in oncologic patients: treatment of acute cutaneous toxicity secondary to radiotherapy.

Abstract

OBJECTIVE:

The objective of this study is to evaluate the efficiency of SOD applied topically in oncologic patients affected by acute radiodermatitis.

MATERIALS AND METHOD:

This study includes 57 patients who showed a dermatitis grade 2 or superior; they were administered SOD ointment b.i.d. (40 mg, weekly) and follow-up continued for 12 weeks.

RESULTS:

At the end of radiotherapy, 77.1% of the patients ameliorated completely or partially, and at the end of the 12-week period 100% of patients were free of toxicity. No acute toxicity relapses were reported. Response time reduced during radiotherapy, as well as the treatment time at the end of it.

CONCLUSIONS:

The employment of SOD topically is efficient in the treatment of radiodermatitis, which is an acute side effect of radiotherapy.

• Authors: Alvaro Manzanas García, María Concepción López Carrizosa, Carmen Vallejo Ocaña, Pilar Samper Ots, José María Delgado Pérez, Emilia Carretero Accame, Pilar Gómez-Serranillos, Luis de la Morena del Valle
• Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (Clin Transl Oncol) Vol. 10 Issue 3 Pg. 163-7 (Mar 2008) ISSN: 1699-048X [Print] Italy
• PMID: 18321819 (Publication Type: Journal Article)

Chemical References

• Free Radical Scavengers
• Ointments
• Superoxide Dismutase

Topics

• Acute Disease
• Administration, Topical
• Adult
• Aged
• Aged, 80 and over
• Female
• Free Radical Scavengers (administration & dosage)
• Humans
• Male
• Middle Aged
• Neoplasms (radiotherapy)
• Ointments
• Radiodermatitis (drug therapy, etiology)
• Radiotherapy (adverse effects)
• Skin (radiation effects)
• Superoxide Dismutase (administration & dosage)
• Treatment Outcome