Early diagnosis of staphylococcal toxic shock syndrome by detection of the TSST-1 Vbeta signature in peripheral blood of a 12-year-old boy.

Abstract

We report the case of a 12-year-old boy who developed staphylococcal toxic shock syndrome associated with S. aureus pharyngeal colonization or infection. The diagnosis was rapidly confirmed by detecting the Vbeta signature of the toxic shock syndrome toxin-1 in peripheral blood, based on transient T cell depletion rapidly followed by massive expansion of Vbeta 2-positive T cells.

• Authors: Tristan Ferry, Damien Thomas, Jean-Christophe Bouchut, Gerard Lina, Maryline Vasselon-Raina, Olivier Dauwalder, Yves Gillet, François Vandenesch, Daniel Floret, Jerome Etienne
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 27 Issue 3 Pg. 274-7 (Mar 2008) ISSN: 0891-3668 [Print] United States
• PMID: 18277923 (Publication Type: Case Reports, Journal Article)

Chemical References

• Bacterial Toxins
• Enterotoxins
• Superantigens
• enterotoxin F, Staphylococcal

Topics

• Bacterial Toxins (immunology)
• Child
• Early Diagnosis
• Enterotoxins (immunology)
• Humans
• Lymphocyte Subsets (immunology)
• Male
• Shock, Septic (diagnosis, immunology)
• Staphylococcal Infections (diagnosis, immunology)
• Superantigens (immunology)
• T-Lymphocytes (immunology)