Neuromuscular painful disorders: a rare side effect of voriconazole in lung transplant patients under tacrolimus.

Abstract

Voriconazole is an anti-fungal agent active against Aspergillus infection that is used for prophylaxis and curative treatment in lung transplant patients. We present nine cases of painful neuromuscular disorders, an unusual and rare side effect of high-dose voriconazole in association with tacrolimus.

• Authors: V Boussaud, N Daudet, E M Billaud, A Lillo-Le Louet, P Chevalier, C Amrein, M Maud Bergé, R Guillemain, C Le Beller
• Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (J Heart Lung Transplant) Vol. 27 Issue 2 Pg. 229-32 (Feb 2008) ISSN: 1557-3117 [Electronic] United States
• PMID: 18267232 (Publication Type: Journal Article)

Chemical References

• Pyrimidines
• Triazoles
• Voriconazole
• Tacrolimus

Topics

• Adolescent
• Adult
• Aspergillosis (drug therapy)
• Cohort Studies
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Drug Interactions
• Drug Therapy, Combination
• Female
• Follow-Up Studies
• Graft Rejection (microbiology, prevention & control)
• Humans
• Lung Transplantation (adverse effects, methods)
• Male
• Middle Aged
• Neuromuscular Diseases (chemically induced, physiopathology)
• Pain (chemically induced, physiopathology)
• Postoperative Complications (microbiology, prevention & control)
• Pyrimidines (adverse effects, therapeutic use)
• Retrospective Studies
• Risk Assessment
• Severity of Illness Index
• Tacrolimus (therapeutic use)
• Treatment Outcome
• Triazoles (adverse effects, therapeutic use)
• Voriconazole