[Prognostic factors of pneumococcal meningitis. Retrospective study of 31 cases].

Abstract

AIM:

Our aim was to study the susceptibility of Streptococcus pneumoniae to antibiotics in patients with pneumococcal meningitis and to search for the prognosis factors in those patients.

METHODS:

We have studied retrospectively 31 cases of pneumococcal meningitis. Comparaisons were performed with univariate analysis.

RESULTS:

The mean age was 36.7 +/- 20.5 years (ranged: 9 and 78 years). The sex ratio was 3,4. The susceptibility of Streptococcus pneumoniae to penicillin G was affected in 10 cases (33% of isolated pneumococcus. The MIC to penicillin G was > or =2 in only one case. The hospital mortality was 26% (8/31). With univariate analysis, factors associated with death were: age > or =55 years (Ss p= 0,006, OR: 17.2 IC95%: 2.3-134), albuminorachie > or = 7 g/l (p = 0.002, OR: 22; IC95%: 1.9-2.51), shock (p = 0.031, OR: 6.7; IC95%: 1.05-42) and Glasgow Coma Score (GCS) < or =8 (p = 0.001, OR: 20; IC95%: 2.68-149).

CONCLUSION:

No susceptibility to penicillin G is not associated with a worse outcome in patients with pneumococcal meningitis. An age > or =55 years, albuminorachie > or =7 g/l shock and Glasgow Coma Score < or =8 at admission were determinant of the prognosis in our study.

• Authors: H Kallel, I Mâaloul, F Mahjoubi, H Dammak, H Ghorbel, H Chelly, H Ksibi, C Ben Hamida, N Rekik, M Ben Jemaa, A Hammami, M Bouaziz
• Journal: La Tunisie medicale (Tunis Med) Vol. 85 Issue 8 Pg. 692-6 (Aug 2007) ISSN: 0041-4131 [Print] Tunisia
• Vernacular Title: Facteurs de pronostic des méningites à pneumocoque. Etude rétrospective de 31 cas.
• PMID: 18254294 (Publication Type: English Abstract, Journal Article)

Topics

• Adolescent
• Adult
• Aged
• Child
• Female
• Humans
• Male
• Meningitis, Pneumococcal (drug therapy)
• Middle Aged
• Prognosis
• Retrospective Studies
• Streptococcus pneumoniae (drug effects)