Abstract | OBJECTIVE: METHODS: 230 cases of drug-induced liver injury diagnosed clinically in the 302 hospital of PLA were retrospectively studied. The drugs which induced liver injuries were summarized and analyzed. Danan's international consensus criteria and Maria's diagnostic scale were applied to diagnose these 230 cases again and then the differences of diagnostic results were analyzed and compared. RESULTS: The drugs which induced liver injuries in the 230 patients were arranged in order of their usage frequencies: traditional Chinese herbs and the like, antibiotics, antipyretic analgesics, antituberculosis medicines, cardiovascular drugs, over-the-counter health stuff, psychopharmaceuticals, dermatological agents, drug for diabetes, tapazol, and others. Based on the 230 adult inpatients with drug-induced liver injury, according to Danan's international consensus criteria, 149 cases (64.8%), 71 (30.9%) and 10 (4.3%) were classified as drug-related, indeterminate and drug-unrelated respectively; according to Maria's diagnostic scale, not one was a definite drug-induced liver injury, 55 cases (23.9%) were probable, while 126 (54.8%), 33 (14.3%) and 16 (7.0%) were possible, unlikely and excluded respectively. CONCLUSION: The accordance rate of Danan's international consensus criteria and clinical diagnosis was higher than that of Maria's diagnostic scale. Neverthelessìthe current diagnostic methods for drug-induced liver injury need to be revised for clinical practice.
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Authors | Biao Xu, Wei-Ping He, Ai-Min Zhang, Jing Chen, Guo-Ping Wang, Ye-Dong Wang, Hui-Fen Wang, Jin-Hua Hu |
Journal | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
(Zhonghua Gan Zang Bing Za Zhi)
Vol. 15
Issue 12
Pg. 926-9
(Dec 2007)
ISSN: 1007-3418 [Print] China |
PMID | 18171529
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Adolescent
- Adult
- Aged
- Chemical and Drug Induced Liver Injury
(classification, diagnosis)
- Female
- Humans
- Liver Diseases
(diagnosis)
- Male
- Middle Aged
- Reference Standards
- Retrospective Studies
- Young Adult
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