Dilation of renal artery stenosis after administration of losartan.

Abstract

Transluminal angioplasty with a balloon catheter is effective to dilate renal artery stenosis (RAS) caused by fibromuscular dysplasia (FMD), but lesions resistant to the angioplasty exist. In this report, we describe the case of a young woman with RAS of FMD that was difficult to dilate even by cutting-balloon angioplasty. To facilitate the formation of a smooth intimal covering at the site of angioplasty, we administered losartan, an angiotensin receptor blocker, for 4 months after the angioplasty. Although re-stenosis was detected at 5 months after the angioplasty, the normotensive state continued without antihypertensives and the re-stenosis gradually dilated afterwards. The present case suggests the possibility of remodeling the renal artery during the normotensive state by administering losartan after the angioplasty.

• Authors: Masayuki Tanemoto, Kei Takase, Takayuki Yamada, Akihiro Satoh, Takaaki Abe, Sadayoshi Ito
• Journal: Hypertension research : official journal of the Japanese Society of Hypertension (Hypertens Res) Vol. 30 Issue 10 Pg. 999-1002 (Oct 2007) ISSN: 0916-9636 [Print] England
• PMID: 18049033 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antihypertensive Agents
• Losartan

Topics

• Adult
• Angioplasty, Balloon
• Antihypertensive Agents (therapeutic use)
• Female
• Fibromuscular Dysplasia (complications)
• Humans
• Hypertension, Renovascular (complications, etiology)
• Losartan (therapeutic use)
• Renal Artery Obstruction (drug therapy, etiology, therapy)
• Treatment Failure