The antimicrobial peptide tachyplesin III coated alone and in combination with intraperitoneal piperacillin-tazobactam prevents ureteral stent Pseudomonas infection in a rat subcutaneous pouch model.

Abstract	We investigated the efficacy of Tachyplesin III alone or combined with piperacillin-tazobactam (TZP) to prevent biofilm formation in vitro and in a rat model of Pseudomonas aeruginosa ureteral stent infection. We have observed that in vitro TZP, in presence of Tachyplesin III, showed minimal inhibitory concentrations (MIC)s twofold and minimal bactericidal concentrations (MBC)s eightfold lower. The in vivo study showed that rats that received intraperitoneal TZP showed the lowest bacterial numbers. Tachyplesin III combined with TZP showed efficacies higher than that of each single compound. Coating ureteral stents with Tachyplesin III is able to inhibit bacterial growth up to 1,000 times.
Authors	Daniele Minardi, Roberto Ghiselli, Oscar Cirioni, Andrea Giacometti, Wojciech Kamysz, Fiorenza Orlando, Carmela Silvestri, Gianni Parri, Elzbieta Kamysz, Giorgio Scalise, Vittorio Saba, Muzzonigro Giovanni
Journal	Peptides (Peptides) Vol. 28 Issue 12 Pg. 2293-8 (Dec 2007) ISSN: 0196-9781 [Print] United States
PMID	18022289 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anti-Bacterial Agents Antimicrobial Cationic Peptides DNA-Binding Proteins Peptides, Cyclic tachyplesin peptide, Tachypleus tridentatus Piperacillin, Tazobactam Drug Combination Penicillanic Acid Piperacillin
Topics	Animals Anti-Bacterial Agents (administration & dosage) Antimicrobial Cationic Peptides (administration & dosage) Bacterial Adhesion Biofilms (drug effects, growth & development) Colony Count, Microbial DNA-Binding Proteins (administration & dosage) Disease Models, Animal Drug-Eluting Stents In Vitro Techniques Male Penicillanic Acid (administration & dosage, analogs & derivatives) Peptides, Cyclic (administration & dosage) Piperacillin (administration & dosage) Piperacillin, Tazobactam Drug Combination Pseudomonas Infections (microbiology, prevention & control) Pseudomonas aeruginosa (drug effects, pathogenicity, physiology) Rats Rats, Wistar Ureteral Diseases (microbiology, prevention & control)

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