Abstract | BACKGROUND: METHODS: We treated 19 children with head-and-neck rhabdomyosarcoma with FSRT (n = 14) or IMRT (n = 5) as a part of multimodal therapy. Median age at the time of radiation therapy was 5 years (range 2-15 years). All children received systemic chemotherapy according to the German Soft Tissue Sarcoma Study protocols. Median size of treatment volume for RT was 93,4 ml. We applied a median total dose of 45 Gy (range 32 Gy - 54 Gy) using a median fractionation of 5 x 1,8 Gy/week (range 1,6 Gy - 1,8 Gy). The median time interval between primary diagnosis and radiation therapy was 5 months (range 3-9 months). RESULTS: After RT, the 3- and 5-year survival rate was 94%. The 3- and 5-year actuarial local control rate after RT was 89%. The actuarial freedom of distant metastases rate at 3- and 5-years was 89% for all patients. Radiotherapy was well tolerated in all children and could be completed without interruptions > 4 days. No toxicities >CTC grade 2 were observed. The median follow-up time after RT was 17 months. CONCLUSION: IMRT and FSRT lead to excellent outcome in children with head-and-neck RMS with a low incidence of treatment-related side effects.
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Authors | Stephanie E Combs, Wolfgang Behnisch, Andreas E Kulozik, Peter E Huber, Jürgen Debus, Daniela Schulz-Ertner |
Journal | BMC cancer
(BMC Cancer)
Vol. 7
Pg. 177
(Sep 13 2007)
ISSN: 1471-2407 [Electronic] England |
PMID | 17854490
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adolescent
- Child
- Child, Preschool
- Combined Modality Therapy
- Dose Fractionation, Radiation
- Female
- Head and Neck Neoplasms
(radiotherapy)
- Humans
- Male
- Radiotherapy, Computer-Assisted
- Radiotherapy, Intensity-Modulated
- Rhabdomyosarcoma
(radiotherapy)
- Stereotaxic Techniques
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