Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma with a CD15(+)CD30(-) phenotype.

Abstract

Primary cutaneous aggressive epidermotropic CD8(+) T-cell lymphoma (CD8(+)TCL) is an extremely rare entity with distinct clinicopathological features. While the CD15 antigen is typically associated with classic Hodgkin's lymphoma, aggressive peripheral T-cell lymphomas, including advanced stage cutaneous T-cell lymphomas, rarely express this molecule. We report a case of primary cutaneous aggressive epidermotropic CD8(+)TCL, in which lymphoma cells are CD15(+)CD30(-) with a medium-to-large pleomorphic phenotype. Although the functional characteristics of CD15 expression in the cutaneous lymphomas are not fully understood, the poor prognosis of primary cutaneous aggressive epidermotropic CD8(+)TCL might be associated with the presence of this molecule in our case.

• Authors: Naho Yoshizawa, Hiroaki Yagi, Takahiro Horibe, Masahiro Takigawa, Makoto Sugiura
• Journal: European journal of dermatology : EJD (Eur J Dermatol) 2007 Sep-Oct Vol. 17 Issue 5 Pg. 441-2 ISSN: 1167-1122 [Print] France
• PMID: 17673391 (Publication Type: Case Reports, Journal Article)

Chemical References

• Ki-1 Antigen
• Lewis X Antigen

Topics

• Aged
• CD8-Positive T-Lymphocytes (immunology)
• Flow Cytometry
• Humans
• Immunohistochemistry
• Ki-1 Antigen (analysis)
• Lewis X Antigen (analysis)
• Lymphoma, T-Cell, Cutaneous (diagnosis, immunology)
• Male
• Prognosis
• Skin Neoplasms (diagnosis, immunology)