Abstract | BACKGROUND: PATIENTS AND METHODS: Serum levels of P1NP, CA 15-3 and CA 125 were analyzed using specific immunoassays. Baseline serum samples of 66 patients with metastatic breast cancer and 34 patients with metastatic ovarian cancer under chemotherapy were investigated. RESULTS: P1NP concentrations were elevated in up to 70% of patients with confirmed bone metastases. The P1NP levels were significantly higher in patients with bone metastases (median: 134 ng/ml) than in those without bone spread (median: 58.5 ng/ml). CONCLUSION: Markers of biochemical bone remodeling can be used in assessing and managing patients with malignancies that metastasize to bone. These markers are abnormally raised in the blood of patients with metastatic bone disease.
|
Authors | Gerhard Oremek, Hildegund Sauer-Eppel, Martina Klepzig |
Journal | Anticancer research
(Anticancer Res)
2007 Jul-Aug
Vol. 27
Issue 4A
Pg. 1961-2
ISSN: 0250-7005 [Print] Greece |
PMID | 17649805
(Publication Type: Journal Article)
|
Chemical References |
- Biomarkers, Tumor
- CA-125 Antigen
- Collagen Type I
- Mucin-1
|
Topics |
- Biomarkers, Tumor
(blood)
- Bone Neoplasms
(blood, secondary)
- Breast Neoplasms
(blood, pathology)
- CA-125 Antigen
(blood)
- Collagen Type I
(blood)
- Female
- Humans
- Mucin-1
(blood)
- Ovarian Neoplasms
(blood, pathology)
- Prognosis
- Sensitivity and Specificity
|