Melanotic neuroectodermal tumor of infancy: report of a case with myogenic differentiation.

Abstract

An 8-month-old boy presented with a 6-week history of a skull mass of the anterior fontanelle. The mass was excised, and the histopathologic features were diagnostic for melanotic neuroectodermal tumor of infancy. The tumor showed focal myogenin positivity, which has not been previously reported in this tumor. The patient has no evidence of recurrent tumor 10 months after the excision. No adjuvant therapy was given. In addition, we stained a case of melanotic neuroectodermal tumor of infancy obtained from Columbus Children's Hospital; focal myogenin positivity was present.

• Authors: Dale A Ellison, Badih Adada, Stephen J Qualman, David M Parham
• Journal: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society (Pediatr Dev Pathol) 2007 Mar-Apr Vol. 10 Issue 2 Pg. 157-60 ISSN: 1093-5266 [Print] United States
• PMID: 17378694 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigens, Neoplasm
• Melanoma-Specific Antigens
• Myogenin
• Neoplasm Proteins
• Keratins
• Phosphopyruvate Hydratase

Topics

• Antigens, Neoplasm
• Follow-Up Studies
• Humans
• Immunohistochemistry
• Infant
• Keratins (metabolism)
• Male
• Melanoma-Specific Antigens
• Myogenin (metabolism)
• Neoplasm Proteins (metabolism)
• Neuroectodermal Tumor, Melanotic (diagnosis, diagnostic imaging, metabolism, pathology, surgery)
• Phosphopyruvate Hydratase (metabolism)
• Radiography
• Skull Neoplasms (diagnosis, diagnostic imaging, metabolism, pathology, surgery)
• Time Factors
• Treatment Outcome