Anti-MAG/SGPG associated neuropathy does not commonly cause distal nerve temporal dispersion.

Abstract

Patients with anti-myelin associated glycoprotein (anti-MAG) neuropathy have uniform slowing without temporal dispersion, but do usually have disproportionately distal slowing. We evaluated distal compound muscle action potential (CMAP) dispersion in 29 patients with anti-MAG/sulphated glucuronyl paragloboside (SGPG) neuropathy (titres > or = 12,800). Among 138 motor responses, 15% (tibial), 7.3% (peroneal), 10.7% (median) and 13.8% (ulnar) had distal CMAP duration > 9 ms. Disproportionate distal slowing with normal distal CMAP duration in the arms may be useful to differentiate chronic inflammatory demyelinating polyneuropathy from anti-MAG/SGPG associated neuropathy.

• Authors: F A A Gondim, E A De Sousa, N Latov, H W Sander, R L Chin, T H Brannagan
• Journal: Journal of neurology, neurosurgery, and psychiatry (J Neurol Neurosurg Psychiatry) Vol. 78 Issue 8 Pg. 902-4 (Aug 2007) ISSN: 1468-330X [Electronic] England
• PMID: 17353253 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies
• Globosides
• Myelin-Associated Glycoprotein
• sulfate-3-glucuronyl paragloboside

Topics

• Action Potentials
• Antibodies
• Arm (physiology)
• Electrophysiology
• Female
• Globosides (immunology)
• Humans
• Male
• Middle Aged
• Muscle, Skeletal (physiopathology)
• Myelin-Associated Glycoprotein (immunology)
• Polyneuropathies (immunology, physiopathology)
• Retrospective Studies