Local high-dose radiotherapy and sparing of normal tissue using intensity-modulated radiotherapy (IMRT) for mucosal melanoma of the nasal cavity and paranasal sinuses.

Abstract

PURPOSE:

To evaluate the clinical outcome of intensity-modulated radiotherapy (IMRT) in patients with mucosal melanoma (MM) of the nasal cavity and paranasal sinuses.

PATIENTS AND METHODS:

Between January 1999 and September 2004, eight patients with histologically proven MM of the nasal cavity and paranasal sinuses were treated with IMRT. A median dose of 66 Gy was applied to the macroscopic tumor (gross tumor volume [GTV]; range, 60-68 Gy) as an integrated boost and a median dose of 59 Gy (range, 54-64 Gy) to the clinical target volume (CTV) with IMRT.

RESULTS:

Treatment-related toxicity was very mild in most patients. Overall survival was 80% at 5 years. Calculated from treatment with IMRT as primary radiotherapy, survival was 100% at 1 year and 75% at 3 years. After IMRT, local progression-free survival was 71.4% at 1 year and 57.1% at 3 years, respectively. Distant progression-free survival after IMRT was 57.1% at 1 year and 28.6% at 3 years.

CONCLUSION:

Local dose escalation with IMRT yields good treatment results with respect to local and distant tumor control as well as survival, while treatment-related toxicity can be minimized.

• Authors: Stephanie E Combs, Stephan Konkel, Christoph Thilmann, Jürgen Debus, Daniela Schulz-Ertner
• Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (Strahlenther Onkol) Vol. 183 Issue 2 Pg. 63-8 (Feb 2007) ISSN: 1439-099X [Electronic] Germany
• PMID: 17294109 (Publication Type: Clinical Trial, Journal Article)

Topics

• Adolescent
• Adult
• Aged
• Dose Fractionation, Radiation
• Female
• Humans
• Male
• Melanoma (radiotherapy)
• Middle Aged
• Nasal Cavity (radiation effects)
• Nasal Mucosa (radiation effects)
• Paranasal Sinus Neoplasms (radiotherapy)
• Radiation Injuries (etiology, prevention & control)
• Radiation Protection (methods)
• Radiotherapy, Conformal (adverse effects, methods)
• Survival Analysis
• Survival Rate
• Treatment Outcome