[Electrophysiological effects of acehytisine hydrochloride in a porcine model of acute coronary occlusion].

Abstract

OBJECTIVE:

To observe the electrophysiological effect of Acehytisine Hydrochloride (AHH) in Wu Zhi Shan (WZS) micropigs with experimental acute coronary occlusion.

METHODS:

Adult WZS micropigs were randomized into group A: coronary ligation with AHH infusion (n = 9); group B: AHH infusion without coronary ligation (n = 9) and group C: coronary ligation with saline (NS) infusion (n = 9). Surface ECGs and cardiac electrophysiological data including atrium, atrium-ventricle junction and ventricle electrograms were collected by programmed electrical stimulation at ischemic baseline and after AHH (or NS) infusion.

RESULTS:

Compared to animals treated with AHH without ischemia, VARC-ERP was significantly increased while QT, QTc intervals, VRRP and VFRP were significantly reduced in ischemic animals treated with AHH. Compared to ischemic animals treated with saline, AHH prolongs the P-wave duration and PR interval, shortens QTc interval, prolongs ARP and AEP, also prolongs V-A reverse conduction time and VARC-ERP but shortens VFRP. No proarrhythmia effect was found in both AHH treated groups.

CONCLUSION:

AHH resulted in significant electrophysiological effects on this porcine acute coronary ischemic model.

• Authors: Yan Liang, Jun Zhu, Yan-min Yang, Jian-dong Li, Yan Sun, Jian Guan, Xin Gao, Chang-rui Li, Yue Tang
• Journal: Zhonghua xin xue guan bing za zhi (Zhonghua Xin Xue Guan Bing Za Zhi) Vol. 34 Issue 11 Pg. 1035-9 (Nov 2006) ISSN: 0253-3758 [Print] China
• PMID: 17288772 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal

Topics

• Aconitum
• Animals
• Coronary Disease (drug therapy, physiopathology)
• Disease Models, Animal
• Drugs, Chinese Herbal (pharmacology)
• Electrophysiology
• Female
• Male
• Phytotherapy
• Random Allocation
• Swine
• Swine, Miniature