Abstract | BACKGROUND/AIMS: METHODS/RESULTS: A total of 181 patients with first anterior ST-elevation AMI were examined. MR was detected in 68 patients by color Doppler echocardiography 2 weeks after AMI, and the patients with MR were associated with higher incidence of readmission for heart failure. Serum CRP was serially measured, and the peak serum CRP level was markedly increased in patients with MR compared with those without MR. Multiple logistic regression analysis showed that peak CRP tertile was an independent determinant of MR after AMI (p < 0.0001). In the substudy, the increases in LV end-diastolic volume and sphericity index were higher in patients with MR than in those without MR. CONCLUSIONS: MR during the early phase of anterior AMI was associated with LV spherical change and late-phase heart failure, in association with increased serum CRP level. These findings suggest an important role of the inflammatory response in the development of ischemic MR and LV remodeling.
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Authors | Takashi Kohno, Toshihisa Anzai, Kotaro Naito, Yohei Ohno, Hidehiro Kaneko, Hui-Chong Li, Yasuo Sugano, Yuichiro Maekawa, Shiro Iwanaga, Yasushi Asakura, Tsutomu Yoshikawa, Satoshi Ogawa |
Journal | Cardiology
(Cardiology)
Vol. 107
Issue 4
Pg. 386-94
( 2007)
ISSN: 1421-9751 [Electronic] Switzerland |
PMID | 17284900
(Publication Type: Journal Article)
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Copyright | 2007 S. Karger AG, Basel |
Chemical References |
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Topics |
- Aged
- C-Reactive Protein
(analysis, immunology)
- Female
- Humans
- Male
- Middle Aged
- Mitral Valve Insufficiency
(blood, etiology, immunology)
- Myocardial Infarction
(blood, complications, immunology)
- Prospective Studies
- Ventricular Remodeling
(immunology)
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