Slow-releasing tranilast in polytetrafluoroethylene/polylactide-co-glycolide laminate delays adjustment after strabismus surgery in rabbit model.

Abstract

PURPOSE:

To determine the usefulness of slow-releasing tranilast in polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate for delayed adjustable strabismus surgery.

METHODS:

A prospective, masked-observer, controlled study was performed in 25 rabbits. Fifty rabbit eyes were divided randomly into three groups. After a recession of the superior rectus muscle (SRM), a PTFE/PLGA laminate containing tranilast, PTFE alone, or balanced salt solution was applied beneath and over the SRM in the PTFE/PLGA-tranilast group (group P-T), the PTFE group (group P), and the control group, respectively. Delayed adjustment was performed by a masked observer once on each SRM 3 or 5 weeks after surgery. Adjustability, adjustment lengths, forces required, and adhesion degrees were evaluated.

RESULTS:

In the control group, adjustment was impossible in any eye 3 or 5 weeks after surgery. In group P, adjustment was possible in 5 of 8 eyes 3 weeks after surgery and in 5 of 10 eyes 5 weeks after surgery. In group P-T, adjustment was possible in 8 of 10 eyes 3 and 5 weeks after surgery. On comparing adjustability, a significant difference was observed between group P-T and the control group 3 and 5 weeks after surgery (P = 0.006, P = 0.006, respectively). A significant difference was observed between group P-T and the control group (P = 0.016) in terms of adhesion between SRMs and conjunctivae 5 weeks after surgery.

CONCLUSIONS:

Slow-releasing tranilast in PTFE/PLGA was found to reduce adhesion and allowed delayed adjustment in most eyes for up to 5 weeks after surgery.

• Authors: Min Joung Lee, Su-Eon Jin, Chong-Kook Kim, Ho-Kyung Choung, Jin Wook Jeoung, Hwa Jung Kim, Gheeyoung Choe, Jeong-Min Hwang
• Journal: Investigative ophthalmology & visual science (Invest Ophthalmol Vis Sci) Vol. 48 Issue 2 Pg. 699-704 (Feb 2007) ISSN: 0146-0404 [Print] United States
• PMID: 17251468 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Delayed-Action Preparations
• Drug Carriers
• Polymers
• ortho-Aminobenzoates
• Polylactic Acid-Polyglycolic Acid Copolymer
• Polyglycolic Acid
• Lactic Acid
• Polytetrafluoroethylene
• tranilast

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
• Delayed-Action Preparations
• Drug Carriers
• Lactic Acid
• Models, Animal
• Oculomotor Muscles (drug effects, pathology)
• Polyglycolic Acid
• Polylactic Acid-Polyglycolic Acid Copolymer
• Polymers
• Polytetrafluoroethylene
• Postoperative Complications (prevention & control)
• Prospective Studies
• Rabbits
• Sclera (drug effects, pathology)
• Strabismus (surgery)
• Suture Techniques
• Tissue Adhesions (prevention & control)
• ortho-Aminobenzoates (administration & dosage)