Hyperoxia attenuates endothelial-mediated vasodilation in the human skin.

Abstract

The influence of hyperoxia on the cutaneous vasodilator responses to iontophoretic applications of acetylcholine (ACh) and sodium nitroprusside (SNP) was examined in healthy subjects. The breathing of 100% O(2) decreased (P < 0.05) the vasodilator response to Ach, but not to SNP, suggesting that hyperoxia attenuates endothelial-mediated vasodilation of the human skin.

• Authors: Fumio Yamazaki
• Journal: The journal of physiological sciences : JPS (J Physiol Sci) Vol. 57 Issue 1 Pg. 81-4 (Feb 2007) ISSN: 1880-6546 [Print] Japan
• PMID: 17169168 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Vasodilator Agents
• Nitroprusside
• Acetylcholine

Topics

• Acetylcholine (administration & dosage)
• Administration, Cutaneous
• Adult
• Blood Flow Velocity
• Endothelium, Vascular (physiopathology)
• Humans
• Hyperoxia (physiopathology)
• Iontophoresis
• Laser-Doppler Flowmetry
• Male
• Microcirculation
• Nitroprusside (administration & dosage)
• Skin (blood supply)
• Time Factors
• Vasodilation (drug effects)
• Vasodilator Agents (administration & dosage)