Abstract | INTRODUCTION: CASE REPORT: Woman diagnosed of prolidase deficiency with leg recalcitrant and infected ulcerations. Dermatology service solicits a proline and glycline containing ointment after failing other topical treatment and a skin grafting. After initiation of treatment, ulcerations improved partially. FORMULA DESCRIPTION: According to "Real Decreto 175/2001, de 23 de febrero", Pharmacy service draws up an elaboration guide and a patient information leaflet of a proline 5%- glycine 5% water emulsive ointment. DISCUSSION: Topical application of a glycine- proline ointment is an alternative for the treatment of recalcitrant ulcerations and it has resulted in variable response. In our patient it has been effective, with a partial improvement of leg ulcerations and a decrease in admissions due to over infection.
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Authors | M P Ortega García, M A Cánoves Escolano, P Blasco Segura, M L García Melgares |
Journal | Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria
(Farm Hosp)
2006 Sep-Oct
Vol. 30
Issue 5
Pg. 304-8
ISSN: 1130-6343 [Print] Spain |
Vernacular Title | Tratamiento efectivo con un ungüento de glicina y prolina en un caso de úlceras recurrentes por déficit de prolidasa. |
PMID | 17166065
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Ointments
- Proline
- Dipeptidases
- proline dipeptidase
- Glycine
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Topics |
- Administration, Topical
- Amino Acid Metabolism, Inborn Errors
(drug therapy, enzymology)
- Dipeptidases
(deficiency)
- Female
- Glycine
(metabolism, therapeutic use)
- Humans
- Leg Ulcer
(drug therapy, enzymology)
- Middle Aged
- Ointments
(administration & dosage)
- Proline
(metabolism, therapeutic use)
- Secondary Prevention
- Treatment Outcome
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