Can Levovist-enhanced Doppler ultrasound replace angiography in renal arteries imaging?

Abstract

BACKGROUND:

To evaluate the diagnostic efficacy of ultrasound imaging of renal arteries after Levovist administration.

MATERIAL/METHODS:

During a 20-month period, 100 hypertensive patients with suspected renal artery stenosis were referred to the Department of Interventional Radiology. In all patients, angiography and ultrasound examinations of renal arteries were performed (100 right, 100 left and 23 additional), before and after Levovist injection, using color and spectral Doppler. Results of Doppler examinations before and after Levovist administration were compared with results of angiography ('gold standard '). Hemodynamically significant renal artery stenoses (> 50% in angiography)were diagnosed following Doppler parameters: Vmax > 2 m/s, V min > 1.5 m/s, RAR > 3.5, acceleration time > 0.08 s.

RESULTS:

The diagnostic efficacy of Doppler examinations of the right renal artery (RRA)increased from 68% before to 98% after Levovist enhancement and diagnostic efficacy for the left renal artery (LRA) increased from 61% to 97%. In conventional study, 7 additional renal arteries (30.4%) were visualized, after Levovist administration this number increased to 15 (65.2%). Before Levovist injection, 3 stenoses of RRA and 1 stenosis of LRA were diagnosed. After Levovist enhancement, the number of RRA stenoses increased to 5 and that of LRA stenoses increased to 2, later confirmed by angiography.

CONCLUSIONS:

The use of Levovist increases the diagnostic efficacy of Doppler ultrasound examinations of renal arteries and makes it comparable to angiography.

• Authors: Anna Drelich-Zbroja, Tomasz Jargiełło, Anna Szymańska, Wojciech Krzyzanowski, Małgorzata Szczerbo-Trojanowska
• Journal: Medical science monitor : international medical journal of experimental and clinical research (Med Sci Monit) Vol. 10 Suppl 3 Pg. 36-41 (Jun 2004) ISSN: 1643-3750 [Electronic] United States
• PMID: 16538197 (Publication Type: Evaluation Study, Journal Article)

Chemical References

• Contrast Media
• Polysaccharides
• SHU 508

Topics

• Adult
• Aged
• Angiography (methods)
• Contrast Media
• Female
• Humans
• Hypertension, Renovascular (diagnostic imaging, etiology)
• Male
• Middle Aged
• Polysaccharides
• Predictive Value of Tests
• Renal Artery (diagnostic imaging)
• Renal Artery Obstruction (complications, diagnostic imaging)
• Ultrasonography, Doppler, Color (methods)