Syringoma-like eccrine sweat duct proliferation induced by radiation.

Abstract

We report a 45-year-old woman with breast cancer who had undergone surgery and radiation and anti-estrogen therapy and presented with many reddish papules in the irradiated breast area. Skin biopsy of the affected area disclosed proliferation of eccrine sweat ducts and cystic structures; the clinical and histopathological features were consistent with syringoma-like eccrine sweat duct proliferation. The lesions spread rapidly on her chest during radiation therapy and regressed spontaneously 3 weeks after its completion. We postulate that the lesions were induced by radiation, and promoted by anti-estrogen therapy.

• Authors: Noriko Yoshii, Takuro Kanekura, Hisahiko Churei, Tamotsu Kanzaki
• Journal: The Journal of dermatology (J Dermatol) Vol. 33 Issue 1 Pg. 36-9 (Jan 2006) ISSN: 0385-2407 [Print] England
• PMID: 16469082 (Publication Type: Case Reports, Journal Article)

Topics

• Breast Neoplasms (drug therapy, pathology, radiotherapy, surgery)
• Diagnosis, Differential
• Eccrine Glands (pathology)
• Female
• Humans
• Middle Aged
• Neoplasms, Radiation-Induced (diagnosis, etiology, pathology)
• Radiotherapy (adverse effects)
• Sweat Gland Neoplasms (diagnosis, etiology, pathology)
• Syringoma (diagnosis, etiology, pathology)