[Doxorubicin in antiblastic hyperthermic perfusion in the treatment of advanced soft-tissue sarcoma of the limbs].

Abstract

Different antineoplastic drugs have been associated to hyperthermia in the treatment of advanced soft tissue limb sarcoma with a good results in terms of conservative surgery (77%-97%), locoregional control (77%-87%) and overall survival (72%). Two different studies were performed: the first was carried out to analyze the doxorubicin-TNFalpha-hyperthermia association (three different trials) in terms of toxicity and efficacy of the treatment (tumor response, locoregional control, disease free and overall survival). The results showed that the trimodality association (doxorubicin TNFalpha and hyperthermia) is the best regimen able to obtain a 77% of objective response and 77% of limb sparing in patients candidate to amputation but may result in high local toxicity if high temperatures (>41.5 degrees C) were maintained during perfusion. The second study describes the employment of liposomal doxorubicin in hyperthermic antiblastic perfusion (HAP) in terms of tumor response, conservative surgery and toxicity; the maximum tolerable dose (MTD) of doxorubicin was 16 mg/l of perfused limb volume at the temperature of 41.5 degrees C; the conservative surgery was possible in 91% of the cases and mild (grade I and II) toxicity was observed in the perfused limb with high temperature (>41.5 degrees C).

• Authors: F Di Filippo, V Patrizi, F Cavaliere, R Garinei, M Anzà, P Perri, C Botti, S Di Filippo, A Vespa
• Journal: I supplementi di Tumori : official journal of Societa italiana di cancerologia ... [et al.] (Suppl Tumori) 2005 May-Jun Vol. 4 Issue 3 Pg. S126-7 ISSN: 2283-5423 [Print] United States
• Vernacular Title: La doxorubicina nella perfusione ipertermico antiblastica nel trattamento dei sarcomi avanzati dei tessuti molli degli arti.
• PMID: 16437946 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Doxorubicin

Topics

• Antibiotics, Antineoplastic (administration & dosage)
• Chemotherapy, Cancer, Regional Perfusion
• Combined Modality Therapy
• Doxorubicin (administration & dosage)
• Extremities
• Female
• Humans
• Hyperthermia, Induced
• Male
• Middle Aged
• Neoplasm Staging
• Sarcoma (drug therapy, pathology)
• Soft Tissue Neoplasms (drug therapy, pathology)