Abstract | PURPOSE: MATERIALS AND METHODS: Three dogs were imaged 14-37 days following permanent ligation of the left anterior descending coronary artery (LAD). Measurements of the longitudinal relaxation rate R(1) were made prior to EVP 1001-1 administration (20 micromol/kg i.v.) and for one hour thereafter. Triphenyl tetrazolium chloride (TTC) staining was used to document infarction. RESULTS: In normal myocardium, EVP 1001-1 produced a substantial increase in the longitudinal relaxation rate, which remained fairly constant over the postcontrast imaging period (DeltaR1= 1.47 +/- 0.58 sec(-1) (mean +/- SD) at 35 minutes, P < 0.05). In the infarct, the response to EVP 1001-1 was small or negligible (DeltaR1= 0.27 +/- 0.28 sec(-1)). This resulted in a significant postcontrast difference in relaxation rate between normal and infarcted tissue (R1(normal) - R1( infarct) = 1.08 +/- 0.26 sec(-1), P < 0.05). The infarct remained clearly delineated in all animals throughout the steady-state imaging period, and qualitatively matched TTC results. CONCLUSION: The persistent enhancement pattern revealed by MRI following EVP 1001-1 administration may be beneficial for identifying and characterizing myocardial infarction.
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Authors | Pippa Storey, Qun Chen, Wei Li, Peter R Seoane, Phillip P Harnish, Laura Fogelson, Kathleen R Harris, Pottumarthi V Prasad |
Journal | Journal of magnetic resonance imaging : JMRI
(J Magn Reson Imaging)
Vol. 23
Issue 2
Pg. 228-34
(Feb 2006)
ISSN: 1053-1807 [Print] United States |
PMID | 16416440
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)
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Copyright | (c) 2006 Wiley-Liss, Inc. |
Chemical References |
- Contrast Media
- EVP 1001-1
- Manganese
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Topics |
- Animals
- Contrast Media
- Disease Models, Animal
- Dogs
- Magnetic Resonance Imaging
(methods)
- Manganese
- Myocardial Infarction
(diagnosis)
- Radiographic Image Interpretation, Computer-Assisted
- Sensitivity and Specificity
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