Pentamidine is active in a neutropenic murine model of acute invasive pulmonary fusariosis.

Abstract

We studied the efficacy of pentamidine (PNT) as prophylaxis or early treatment in acute pulmonary fusariosis in neutropenic mice. PNT-preexposed mice had significantly improved survival and reduced fungal burden compared to amphotericin B-preexposed and untreated mice. PNT-treated mice had increased survival but no difference in fungal burden versus untreated mice.

• Authors: Michail S Lionakis, Georgios Chamilos, Russell E Lewis, Nathan P Wiederhold, Issam I Raad, George Samonis, Dimitrios P Kontoyiannis
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 50 Issue 1 Pg. 294-7 (Jan 2006) ISSN: 0066-4804 [Print] United States
• PMID: 16377700 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Pentamidine

Topics

• Animals
• Antifungal Agents (pharmacokinetics, therapeutic use)
• Disease Models, Animal
• Fusarium (drug effects, isolation & purification)
• Lung Diseases, Fungal (drug therapy, pathology)
• Mice
• Mice, Inbred BALB C
• Microbial Sensitivity Tests
• Neutropenia (complications, metabolism)
• Opportunistic Infections
• Pentamidine (pharmacology, therapeutic use)