Abstract | OBJECTIVES: METHODS: We assessed the efficacy and safety of a combination therapy including caspofungin in 17 immunosuppressed or postoperative patients progressive despite standard anti-fungal therapy. RESULTS: The infections included aspergillosis (6), invasive candidiasis (9), mucormycosis (1) and Scedosporium pneumonia (1). Infections had failed one to four prior lines of treatment. The anti-fungal agent combined to caspofungin was either an amphotericin B formulation or an azole. There were 12 favourable responses (71%) and five failures. The survival rate at 3 months was 47%. Eleven patients died within 2-533 days. The causes of death included the initial fungal infection (4), relapse of the infection after switching to oral monotherapy (2), breakthrough aspergillosis (1), and the underlying condition (4). Clinical and renal tolerance were good. Significant hepatic abnormalities were recorded in eight (50%) of the 16 patients evaluable for biological tolerance. CONCLUSION:
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Authors | Y Nivoix, A Zamfir, P Lutun, F Kara, V Remy, B Lioure, J C Rigolot, N Entz-Werlé, V Letscher-Bru, J Waller, D Levêque, J C Koffel, L Beretz, R Herbrecht |
Journal | The Journal of infection
(J Infect)
Vol. 52
Issue 1
Pg. 67-74
(Jan 2006)
ISSN: 1532-2742 [Electronic] England |
PMID | 16368463
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antifungal Agents
- Echinocandins
- Lipopeptides
- Peptides, Cyclic
- Amphotericin B
- Fluconazole
- Caspofungin
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Amphotericin B
(administration & dosage, adverse effects, therapeutic use)
- Antifungal Agents
(administration & dosage, therapeutic use)
- Caspofungin
- Child, Preschool
- Drug Therapy, Combination
- Echinocandins
- Fluconazole
(administration & dosage, therapeutic use)
- Humans
- Lipopeptides
- Middle Aged
- Mycoses
(drug therapy)
- Peptides, Cyclic
(administration & dosage, adverse effects, therapeutic use)
- Risk Factors
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