Correlation between reduction potentials and inhibitory effects on Epstein-Barr virus activation by emodin derivatives.

Abstract

As a continuation of studies using natural and synthetic products as cancer chemopreventive agents, we examined the reduction-oxidation potentials of hydroxylated emodin derivatives prepared from emodin in phosphate buffer at pH 7.2 using cyclic voltammetry. A significant correlation was found between the reduction potentials and number of the hydroxyl groups and the inhibitory effects of the hydroxylated emodin derivatives on Epstein-Barr virus early antigen activation. The electronic properties, i.e. LUMO energy and atomic charges of carbon at the 9-position (C(9)) and oxygen at the 11-position (O(11)), may also be useful for estimating the inhibitory effect on EBV-EA activation.

• Authors: Junko Koyama, Munetaka Inoue, Izumi Morita, Norihiro Kobayashi, Toshiyuki Osakai, Hoyoku Nishino, Harukuni Tokuda
• Journal: Cancer letters (Cancer Lett) Vol. 241 Issue 2 Pg. 263-7 (Sep 28 2006) ISSN: 0304-3835 [Print] Ireland
• PMID: 16338070 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Viral
• Enzyme Inhibitors
• Emodin

Topics

• Antigens, Viral (pharmacology)
• Electrochemistry
• Emodin (analogs & derivatives, pharmacology)
• Enzyme Inhibitors (pharmacology)
• Epstein-Barr Virus Infections (drug therapy, virology)
• Herpesvirus 4, Human (drug effects, physiology)
• Humans
• Hydrogen-Ion Concentration
• Nasopharyngeal Neoplasms (drug therapy, virology)
• Oxidation-Reduction
• Virus Activation (drug effects)