Is there any role for sentinel node mapping in colorectal cancer staging? Personal experience and review of the literature.

We explored the role of lymphatic mapping and sentinel lymphadenectomy (originally described for melanoma and breast cancer) in colon cancer. Pathologic techniques can successfully identify micrometastatic disease in lymph nodes, but they are not suitable for clinical routine use. We evaluated the role of sentinel node (SN) mapping in refining the staging of colorectal cancer.
A total of 56 open colorectal resections were performed, and Patent Blue V dye was injected under the serosa surrounding the tumor immediately after opening the abdomen. SNs were analysed by immunohistochemistry to find micrometastatic disease. A literature search for the role of SNs in colorectal cancer was also performed.
We identified the SN in 100% of patients, with a mean of 2.02 SNs/patient (range 1-5). After immunohistochemical staining, we could upstage 21 out of 56 patients (37.5%), and we observed 10.7% false negative SNs (6/56 patients). Fewer than half of the articles described false negative rates of <15%, and most articles showed an upstaging rate of >5% of patients. These differences are probably the result of different sensitivities of the methods used in identifying the lymph node micrometastases.
SN mapping is an easy and cost-effective technique that holds promise and warrants further investigations.
AuthorsC Codignola, F Zorzi, A Zaniboni, S Mutti, A Rizzi, E Padolecchia, G B Morandi
JournalJapanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 35 Issue 11 Pg. 645-50 (Nov 2005) ISSN: 0368-2811 [Print] Japan
PMID16275673 (Publication Type: Journal Article)
  • Adult
  • Aged
  • Aged, 80 and over
  • Colorectal Neoplasms (pathology, surgery)
  • Disease-Free Survival
  • Female
  • Humans
  • Lymph Node Excision
  • Lymph Nodes (pathology)
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Sensitivity and Specificity
  • Sentinel Lymph Node Biopsy (economics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: