Long-term effect of bone marrow transplantation in adult-onset adrenoleukodystrophy.

Abstract

We report a long-term outcome of motor function in a patient with adult-onset adrenoleukodystrophy after bone marrow transplantation (BMT). Clinically motor function gradually improved and became almost normal in 2 years after BMT. Serial transcranial magnetic stimulation showed gradual improvement of central motor conduction until 1 year after BMT, and then it became stable. Central motor conduction time and motor threshold were useful for monitoring the central motor function in this patient.

• Authors: T Hitomi, T Mezaki, H Tomimoto, A Ikeda, S Shimohama, T Okazaki, T Uchiyama, H Shibasaki
• Journal: European journal of neurology (Eur J Neurol) Vol. 12 Issue 10 Pg. 807-10 (Oct 2005) ISSN: 1351-5101 [Print] England
• PMID: 16190920 (Publication Type: Case Reports, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adrenoleukodystrophy (physiopathology, surgery)
• Adult
• Bone Marrow Transplantation (methods)
• Electric Stimulation (methods)
• Evoked Potentials, Motor (physiology)
• Humans
• Male
• Time
• Time Factors