Abstract | PURPOSE: METHODS: From January 1995 to December 1997, 648 consecutive cases of colorectal carcinoma were recorded at the Department of Surgery, National Cancer Center Hospital, Tokyo, Japan. We evaluated clinicopathologic and immunohistochemical factors (age, gender, tumor location, gross type, size, histologic type, dedifferentiation of invasive front, depth of invasion, lymphatic invasion, venous invasion, lymph-node metastasis, and expression of CD10, MUC2, and human gastric mucin) in 505 of these patients who had undergone resection of T2/T3/T4 colorectal carcinomas to clarify the correlation between these factors and liver metastasis. RESULTS: Liver metastases, including unresectable, were detected in 122 patients (24 percent), all of whom had been followed for at least five years. Univariate analysis revealed that liver metastasis was significantly associated with tumor size, histologic type, dedifferentiation of invasive front, depth of invasion, lymphatic invasion, venous invasion, lymph-node metastasis, and CD10 expression. Multivariate analysis revealed that invasion deeper than the subserosa, venous invasion, lymph-node metastasis, and CD10 expression were significantly associated with liver metastases. CONCLUSIONS:
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Authors | Yoshiya Fujimoto, Yukihiro Nakanishi, Shigeki Sekine, Kimio Yoshimura, Takayuki Akasu, Yoshihiro Moriya, Tadakazu Shimoda |
Journal | Diseases of the colon and rectum
(Dis Colon Rectum)
Vol. 48
Issue 10
Pg. 1883-9
(Oct 2005)
ISSN: 0012-3706 [Print] United States |
PMID | 16175325
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Gastric Mucins
- MUC2 protein, human
- Mucin-2
- Mucins
- Neprilysin
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Topics |
- Adenocarcinoma
(chemistry, secondary)
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(analysis)
- Colorectal Neoplasms
(chemistry, pathology)
- Female
- Gastric Mucins
(analysis)
- Humans
- Liver Neoplasms
(chemistry, secondary)
- Male
- Middle Aged
- Mucin-2
- Mucins
(analysis)
- Neoplasm Metastasis
- Neprilysin
(analysis)
- Predictive Value of Tests
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