Lack of effect of Helicobacter pylori on symptom improvement with a prokinetic medication, cisapride, in patients with non-ulcer dyspepsia.

Abstract

OBJECTIVE:

This study was undertaken to determine whether H. pylori infection has an effect on the improvement of dyspeptic symptoms in response to a prokinetic agent, cisapride, in patients with non-ulcer dyspepsia (NUD).

MATERIAL AND METHOD:

35 NUD patients (16 M, 19 F) who had no underlying medical condition and negative upper endoscopy were included in the present study. Each patient received a 2-wk treatment of cisapride (Prepulsid, 10 mg, tid ac). H. pylori infection was determined using a rapid urease test (CLO test). Gastric emptying (GE) scintigraphy and dyspeptic symptom scores were evaluated before and at the end of the treatment. GE was evaluated in 22 healthy volunteers as normal controls.

RESULTS:

Half time (T1/2) GE of NUD patients was 90.9 +/- 28 min which was significantly longer than controls (77.6 +/- 14 min; p < 0.05) and was shortened to 73.6 +/- 22 min (p < 0.0001) at the end of the treatment. Cisapride significantly improved total dyspeptic symptom scores [7 (2-18) to 3 (0-11), p < 0.0001]. The symptom score improvement was not affected by H. pylori infection [H. pylori positive: 6 (2-18) to 2.5 (0-9), p < 0.0001; H. pylori negative: 9 (4-16) to 3 (0-11), p < 0.0001] or GE status [delayed GE: 10 (5-16) to 3 (15), p < 0.05; non delayed GE: 6 (2-18) to 2 (0-11); p < 0.0001].

CONCLUSIONS:

Cisapride improves dyspeptic symptoms regardless of H. pylori and GE status. These results suggest that gastric emptying and H. pylori infection are not essential to determine prior to prescribing a prokinetic agent, cisapride, in patients with NUD.

• Authors: Sutep Gonlachanvit, Varocha Mahachai, Tawatchai Chaiwatanarat, Pinit Kullavanijaya
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 88 Issue 5 Pg. 660-7 (May 2005) ISSN: 0125-2208 [Print] Thailand
• PMID: 16149685 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Cholinergic Agonists
• Gastrointestinal Agents
• Cisapride

Topics

• Adult
• Cholinergic Agonists (administration & dosage, therapeutic use)
• Cisapride (administration & dosage, therapeutic use)
• Drug Administration Schedule
• Dyspepsia (drug therapy, microbiology, physiopathology)
• Female
• Gastric Emptying (drug effects)
• Gastrointestinal Agents (administration & dosage, therapeutic use)
• Helicobacter Infections (complications, physiopathology)
• Helicobacter pylori
• Humans
• Male
• Treatment Outcome