The inhibitory effect and possible mechanisms of D-allose on cancer cell proliferation.

Abstract	Rare sugars are monosaccharides distributed rarely in nature, because of its very limited amount and cost, the biological effect has hardly been studied. Recently, an effective strategy for mass production of rare sugars has been developed. As a result, a wide range of study of rare sugars from the basic to applied research has become possible. For biological application of rare sugars, it is necessary to fundamentally investigate the relationships between rare sugars and living cells in terms of physiology. Therefore, we firstly examined the effect of rare sugars including D-psicose, D-allose, D-altrose and D-talitol on cell proliferation using certain cell lines in vitro. Cell growth was evaluated by MTT assay after 24-, 48- and 72-h treatment. The result shows that D-allose has a significant inhibitory effect on cancer cell proliferation in a dose-dependent manner. Although the exact mechanism remains unclear, this finding represents a novel aspect of the biological profile of D-allose and suggests that D-allose may be an effective adjuvant therapeutic agent against cancer in the future.
Authors	Li Sui, Youyi Dong, Yasuo Watanabe, Fuminori Yamaguchi, Naoya Hatano, Ikuko Tsukamoto, Ken Izumori, Masaaki Tokuda
Journal	International journal of oncology (Int J Oncol) Vol. 27 Issue 4 Pg. 907-12 (Oct 2005) ISSN: 1019-6439 [Print] Greece
PMID	16142305 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Hexoses Monosaccharides Reactive Oxygen Species Sugar Alcohols Tetrazolium Salts Thiazoles psicose Fructose altritol allose DNA thiazolyl blue Glucose
Topics	Apoptosis Blotting, Western Cell Cycle Cell Line, Tumor Cell Proliferation (drug effects) DNA (chemistry) Fructose (pharmacology) Gene Expression Regulation, Neoplastic Glucose (chemistry, pharmacology) HeLa Cells Hexoses (pharmacology) Humans In Situ Nick-End Labeling In Vitro Techniques Models, Chemical Monosaccharides (chemistry) Neoplasms (drug therapy) Reactive Oxygen Species Sugar Alcohols (pharmacology) Tetrazolium Salts (pharmacology) Thiazoles (pharmacology) Time Factors

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