Abstract | BACKGROUND: METHODS AND RESULTS: AGEs ( carboxymethyllysine - ELISA and fluorescent AGEs - spectrofluorimetry) and AOPP (spectrophotometry) were assessed in 42 patients with atherosclerosis and 21 healthy controls. AGEs are significantly elevated in patients with atherosclerosis in comparison with healthy subjects ( carboxymethyllysine 9.02+/-1.66 microg/g prot. vs 7.52+/-1.18 microg/g prot., p<0.001, fluorescent AGEs 4.39 x 103+/-1.15 x 103 AU/g prot. vs 3.78 x 103+/-0.52 x 103 AU/g prot., p<0.001). Mean AOPP concentrations are also slightly higher, but this elevation is not quite significant (95.0+/-42.9 micromol/l vs 79.7+/-28.2 micromol/l, p=0.096). AGEs and AOPP correlate significantly with each other and with selected lipids. Patients with atherosclerosis treated with statins have slightly lower CML, AGEs and AOPP (it did not reach the statistical significance). CONCLUSIONS: Advanced glycoxidation products are elevated in patients with atherosclerosis and are related to parameters of lipid metabolism. Glycoxidation might be possibly therapeutically influenced by statins; however, further clinical studies are required to confirm this hypothesis.
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Authors | M Kalousová, A Zák, J Soukupová, S Stípek, I M Malbohan, T Zima |
Journal | Casopis lekaru ceskych
(Cas Lek Cesk)
Vol. 144
Issue 6
Pg. 385-9; discussion 389-90
( 2005)
ISSN: 0008-7335 [Print] Czech Republic |
Vernacular Title | Produkty pokrocilé glykace a oxidace u pacientů s aterosklerózou. |
PMID | 16047840
(Publication Type: Journal Article)
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Chemical References |
- Blood Proteins
- Glycation End Products, Advanced
- N(6)-carboxymethyllysine
- Lysine
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Topics |
- Arteriosclerosis
(blood, drug therapy)
- Blood Proteins
(metabolism)
- Female
- Glycation End Products, Advanced
(blood)
- Humans
- Lysine
(analogs & derivatives, blood)
- Male
- Middle Aged
- Oxidation-Reduction
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