[Experimental justification of the use of benzimidazole derivatives as antiasthenic agents after craniocerebral trauma].

Abstract

Experimental administration of benzimidazole derivatives upon model craniocerebral trauma favored rapid normalization of the behavior of hypoxia-sensitive animals and prevented from excess activation of lipid peroxidation processes in the brain. It is recommended to use benzimidazole derivatives for the control of free-radical processes and the correction of psychopathologic disorders in cases of post-trauma cerebroasthenia.

• Authors: I V Zarubina, F N Nurmanbetova, P D Shabanov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2005 May-Jun Vol. 68 Issue 3 Pg. 46-9 ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 16047681 (Publication Type: Journal Article)

Chemical References

• Benzimidazoles
• Neuroprotective Agents

Topics

• Animals
• Asthenia (etiology, prevention & control)
• Behavior, Animal (drug effects)
• Benzimidazoles (pharmacology, therapeutic use)
• Brain (drug effects, metabolism)
• Craniocerebral Trauma (drug therapy, metabolism)
• Hypoxia (drug therapy)
• Lipid Peroxidation (drug effects)
• Male
• Neuroprotective Agents (pharmacology, therapeutic use)
• Rats
• Rats, Inbred Strains