Combination of heart-type fatty acid binding protein and brain natriuretic peptide can reliably risk stratify patients hospitalized for chronic heart failure.

Abstract

BACKGROUND:

The aim of the present study was to prospectively study whether a combination of markers for myocardial cell injury and left ventricular overload at admission can reliably risk stratify patients hospitalized for chronic heart failure (CHF).

METHODS AND RESULTS:

Serum concentrations of heart-type fatty acid binding protein (H-FABP) and plasma concentrations of brain natriuretic peptide (BNP) were measured at admission in 186 consecutive patients hospitalized for CHF. During a mean follow-up period of 534+/-350 days, there were 44 cardiac events, including 16 cardiac deaths and 28 readmissions for worsening heart failure. Normal upper limits for H-FABP and BNP values were determined from the receiver operating characteristic curves (4.3 ng/ml for H-FABP and 200 pg/ml for BNP). A stepwise Cox regression analysis demonstrated that high H-FABP (hazard ratio 5.416, p = 0.0002) and high BNP (hazard ratio 2.411, p = 0.0463) were independent predictors of cardiac events. High concentrations of both H-FABP and BNP at admission were associated with the highest incidence of cardiac mortality and cardiac events. Kaplan-Meier analysis also showed that the combination of H-FABP and BNP concentrations could reliably stratify patients for cardiac events.

CONCLUSION:

Combined measurement of H-FABP and BNP concentrations at admission may be a highly reliable evaluation for risk stratifying patients hospitalized for CHF.

• Authors: Takeshi Niizeki, Yasuchika Takeishi, Takanori Arimoto, Tatsuya Takahashi, Hidenobu Okuyama, Noriaki Takabatake, Naoki Nozaki, Osamu Hirono, Yuichi Tsunoda, Tetsuro Shishido, Hiroki Takahashi, Yo Koyama, Akira Fukao, Isao Kubota
• Journal: Circulation journal : official journal of the Japanese Circulation Society (Circ J) Vol. 69 Issue 8 Pg. 922-7 (Aug 2005) ISSN: 1346-9843 [Print] Japan
• PMID: 16041160 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Carrier Proteins
• Fatty Acid-Binding Proteins
• Natriuretic Peptide, Brain

Topics

• Aged
• Biomarkers (blood)
• Carrier Proteins (blood)
• Fatty Acid-Binding Proteins
• Female
• Heart Failure (blood)
• Hospitalization
• Humans
• Male
• Middle Aged
• Natriuretic Peptide, Brain (blood)
• Patient Selection
• Prospective Studies
• Risk Factors