Comparison of autologous cell therapy and granulocyte-colony stimulating factor (G-CSF) injection vs. G-CSF injection alone for the treatment of acute radiation syndrome in a non-human primate model.

Abstract

PURPOSE:

To compare the efficacy of autologous cell therapy after irradiation combined with granulocyte-colony stimulating factor (G-CSF) injections with G-CSF treatment alone in a heterogeneous model of irradiation representative of an accidental situation.

MATERIAL AND METHODS:

Non-human primates were irradiated at 8.7 Gy whole-body dose with the right arm shielded to receive 4.8 Gy. The first group of animals received G-CSF (lenograstim) injections starting 6 h after irradiation, and a second group received a combination of G-CSF (lenograstim) injections and autologous expanded hematopoietic cells. Animals were followed up for blood cell counts, circulating progenitors, and bone marrow cellularity.

RESULTS:

No significant differences were seen between the two treatment groups, whatever the parameter observed: time to leukocyte or platelet recovery and duration and severity of aplasia.

CONCLUSION:

Our results indicated that identical recovery kinetic was observed when irradiated animals are treated with G-CSF independently of the reinjection of ex vivo expanded autologous hematopoietic cells. Thus G-CSF injections might be chosen as a first-line therapeutic strategy in the treatment of accidental acute radiation victims.

• Authors: Jean-Marc Bertho, Johanna Frick, Marie Prat, Christelle Demarquay, Nicolas Dudoignon, François Trompier, Norbert-Claude Gorin, Dominique Thierry, Patrick Gourmelon
• Journal: International journal of radiation oncology, biology, physics (Int J Radiat Oncol Biol Phys) Vol. 63 Issue 3 Pg. 911-20 (Nov 01 2005) ISSN: 0360-3016 [Print] United States
• PMID: 15913916 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Recombinant Proteins
• Granulocyte Colony-Stimulating Factor
• Lenograstim

Topics

• Animals
• Combined Modality Therapy
• Granulocyte Colony-Stimulating Factor (therapeutic use)
• Hematopoiesis (radiation effects)
• Hematopoietic Stem Cell Transplantation (methods)
• Lenograstim
• Macaca fascicularis
• Male
• Radiation Injuries, Experimental (therapy)
• Recombinant Proteins (therapeutic use)
• Syndrome
• Treatment Outcome