Anti-metastatic effects of curcusone B, a diterpene from Jatropha curcas.

Abstract

A new approach to cancer therapy in recent years has been to target the metastatic process. The anti-metastatic potential of curcusone B, a diterpene isolated from Jatropha curcas Linn. (Euphorbiaceae), a herbal plant that has been used in traditional folk medicine in many tropical countries, was investigated against 4 human cancer cell lines. Treatment with non-cytotoxic doses of curcusone B resulted in a strong reduction of in vitro invasion, motility and secretion of matrix-metalloproteinases (MMP) of the cancer cells, whereas the ability to adhere to a Matrigel-coated surface was variably sensitive to curcusone B treatment. Curcusone B, thus, effectively suppresses the metastatic processes at doses that are non-toxic to cells, which may be of therapeutic benefit for the treatment of metastatic cancers.

• Authors: Surin Muangman, Montri Thippornwong, Rutaiwan Tohtong
• Journal: In vivo (Athens, Greece) (In Vivo) 2005 Jan-Feb Vol. 19 Issue 1 Pg. 265-8 ISSN: 0258-851X [Print] Greece
• PMID: 15796185 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Diterpenes
• Drug Combinations
• Laminin
• Proteoglycans
• curcusone B
• matrigel
• Collagen

Topics

• Adenocarcinoma (pathology)
• Adenoma, Bile Duct (pathology)
• Bile Duct Neoplasms (pathology)
• Breast Neoplasms (pathology)
• Carcinoma, Hepatocellular (pathology)
• Cell Adhesion (drug effects)
• Cell Line, Tumor
• Cell Movement (drug effects)
• Cell Survival (drug effects)
• Collagen (drug effects)
• Diterpenes (chemistry, pharmacology)
• Drug Combinations
• Female
• Humans
• Jatropha (chemistry)
• KB Cells
• Laminin (drug effects)
• Liver Neoplasms (pathology)
• Neoplasm Invasiveness (prevention & control)
• Neoplasm Metastasis (prevention & control)
• Plants, Medicinal
• Proteoglycans (drug effects)