Excessive matrix metalloproteinase-9 in the plasma of community-acquired pneumonia.

Abstract

BACKGROUND:

It has been shown that matrix metalloproteinase-9 (MMP-9) is involved in the pathogenesis of various pulmonary inflammatory diseases. We determined the MMP-9 concentration in the plasma of community-acquired pneumonia (CAP) patients before and after antibiotic treatment.

METHODS:

Gelatin zymography and ELISA analysis were used to measure MMP-9 activity and MMP-9 level, respectively, in 35 control subjects and 46 CAP patients.

RESULTS:

WBC counts, neutrophils, MMP-9 activity and MMP-9 level were significantly higher in CAP patients compared with that of control subjects (P<0.001), while MMP-9 activity and MMP-9 level were returned to normal after the antibiotic treatment (P<0.001). In addition, MMP-9 level correlated positively with WBC counts and neutrophils number both before and after the antibiotic treatment.

CONCLUSIONS:

MMP-9 may play an important role in the pathogenesis of CAP with a positive correlation with the number of neutrophils.

• Authors: Shun-Fa Yang, Shu-Chen Chu, I-Chen Chiang, Wen-Fu Kuo, Hui-Ling Chiou, Fen-Pi Chou, Wu-Hsien Kuo, Yih-Shou Hsieh
• Journal: Clinica chimica acta; international journal of clinical chemistry (Clin Chim Acta) Vol. 352 Issue 1-2 Pg. 209-15 (Feb 2005) ISSN: 0009-8981 [Print] Netherlands
• PMID: 15653116 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Matrix Metalloproteinase 9

Topics

• Adult
• Anti-Bacterial Agents (therapeutic use)
• Community-Acquired Infections (blood, drug therapy, enzymology)
• Female
• Humans
• Male
• Matrix Metalloproteinase 9 (blood)
• Middle Aged
• Pneumonia (blood, drug therapy, enzymology)