Abstract | OBJECTIVES: METHODS: Tc99m-glucoheptonate brain SPECT was performed in 27 patients with medulloblastoma after radiation therapy and with clinical suspicion of tumour recurrence. Histological verification was obtained within 7 days in patients with a SPECT diagnosis of tumour recurrence. Patients with a SPECT diagnosis of post-radiation gliosis were clinically observed for a minimum period of one year after the SPECT study. RESULTS: Fourteen patients had increased radiotracer uptake in the primary tumour bed, suggesting tumour recurrence. Histopathology confirmed viable medulloblastoma in all cases. Thirteen patients had no increased tracer uptake in the primary tumour bed, suggesting post-radiation gliosis. They all had a clinical course consistent with post-radiation gliosis. CONCLUSION: Tc99m-glucoheptonate is an ideal SPECT tracer for functional evaluation of medulloblastoma. SPECT utilising Tc99m-glucoheptonate is a reliable diagnostic modality to differentiate tumour recurrence from post-radiation gliosis in patients with medulloblastoma.
|
Authors | S Barai, G P Bandopadhayaya, P K Julka, S S Kale, R Kumar, A Malhotra, A K Haloi, A Seith, K K Naik, H Dhanapathi |
Journal | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
(J Clin Neurosci)
Vol. 12
Issue 1
Pg. 36-8
(Jan 2005)
ISSN: 0967-5868 [Print] Scotland |
PMID | 15639408
(Publication Type: Journal Article)
|
Chemical References |
- Organotechnetium Compounds
- Radiopharmaceuticals
- Sugar Acids
- technetium Tc 99m gluceptate
|
Topics |
- Adolescent
- Adult
- Cerebellar Neoplasms
(diagnostic imaging, surgery)
- Child
- Data Interpretation, Statistical
- Female
- Follow-Up Studies
- Humans
- Male
- Medulloblastoma
(diagnostic imaging, surgery)
- Middle Aged
- Neurosurgical Procedures
- Organotechnetium Compounds
- Radiopharmaceuticals
- Sugar Acids
- Tomography, Emission-Computed, Single-Photon
|